RESPONSE PEAK UNIBOX TRIAL

However, these studies were based on relatively small sample sizes ( n < 600) or specific population groups such as healthcare workers, potentially reducing generalizability, and antibody levels were measured only at specific times after second doses. Subsequent UK studies showed that extended BNT162b2 dosing intervals generated higher antibody responses than the 3-week interval 7, 8, 9.

RESPONSE PEAK UNIBOX TRIAL

Although the ChAdOx1 trial found higher vaccine efficacy with dosing intervals of at least 6 weeks 6, BNT162b2 trials did not compare different dosing intervals. With widespread Alpha variant transmission, in January 2021 the UK government extended the dosing interval from 3–4 weeks to 12 weeks for all vaccines to maximize first dose coverage, based on preliminary data showing high short-term efficacy from single BNT162b2 (90%) and ChAdOx1 (70%) doses 5.

Up to 4 October 2021, 85% and 78% of the population (aged ≥12 years) have received one and two doses, respectively 4. In the UK, vaccines were initially prioritized to older adults, frontline health and social care workers, and clinically vulnerable individuals, and then offered to other adults in decreasing age order 3. The Pfizer-BioNTech BNT162b2 and Oxford-AstraZeneca ChAdOx1 nCoV-19 (hereafter ChAdOx1) SARS-CoV-2 vaccines have been widely used in the United Kingdom (UK) and worldwide 1, 2. A third booster dose might be needed, prioritized to ChAdOx1 recipients and those more clinically vulnerable. At least 67% protection against infection was estimated to last for 2–3 months after two ChAdOx1 doses, for 5–8 months after two BNT162b2 doses in those without prior infection and for 1–2 years for those unvaccinated after natural infection. Anti-spike IgG levels were associated with protection from infection after vaccination and, to an even greater degree, after prior infection. Prior infection significantly increased antibody peak level and half-life with both vaccines. Older individuals and males had lower peak levels with BNT162b2 but not ChAdOx1, whereas declines were similar across ages and sexes with ChAdOX1 or BNT162b2. After second vaccination, BNT162b2 generated higher peak levels than ChAdOX1. In 222,493 individuals, we found significant boosting of anti-spike IgG by the second doses of both vaccines in all ages and using different dosing intervals, including the 3-week interval for BNT162b2. In this study, we investigated anti-spike IgG antibody responses and correlates of protection after second doses of ChAdOx1 or BNT162b2 vaccines for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in the United Kingdom general population. However, antibody trajectories and the associated duration of protection after a second vaccine dose remain unclear. Unibox has recently undertaken a UK-wide roll out of freestanding merchandising displays for leading sports goods retailer, The FitCo.ĭesigned as highly versatile standalone units, the POS systems have since been installed within a range of outlets run by premier UK leisure club operators.Antibody responses are an important part of immunity after Coronavirus Disease 2019 (COVID-19) vaccination. The shape and colour of the profile's panels and detailing can be designed to coordinate with corporate branding or the merchandise on display. It maximises the display area by making use of often wasted wall space and by allowing merchandise of varying sizes to all be accommodated within the same unit. With this, and Unibox's many other shop fitting options, displays are easily and cost effectively adaptable to changes in stores' stock and layouts. The profile can be wall mounted or installed within Unibox’s existing modular systems, which include RMUs, POS units, kiosks and glass display cabinets. The profile features equally spaced parallel grooves, which allow customisation of the display using a variety of accessories, such as hooks, racks, and shelves. Unibox, manufacturers of modular retail and exhibition display systems, have added a highly flexible slat wall aluminium profile to their range of products.

Response peak unibox